Neurobiology, 2004-08-06

Module: 
Neurobiology
Examiner: 
Brandt
Assessor: 
Weismann
Date: 
Fri, 2004-08-06

Neurobiologie Prüfung

Prüfer: Prof. Brandt

Beisitzerin: Frau Weismann

Datum: 6.8.04

Semester: 4

Note: 1,0

Themen: 20 Minuten allg. Neurobio, 15 Minuten Cerebellum/Basal Ganglien/ Cortex

Fragen:

Which types of cells are there in the CNS besides neuronal cells? Groups (micro/macro glial cells)? Function? Differences between Schwann cells and oligodendrocytes?

What is the blood-brain barrier? What is the function of astrocytes (help to form tight junctions in development)? First and second Goldmann experiment? What is the function of the liquor? How is the one-way system realized?

Explain the parts of a typical neuron.

Neuron malen

How, where and why is an AP generated? Take the example of glutamate receptors and explain what happens in the postsynaptic cell. Where besides the axon hillock can you find voltage gated Na+ channels (nodes of Ranvier)?

Which kind of glutamate receptors do you know? What is the difference between NMDA and non-NMDA receptors? What happens when NMDA receptors open (LTP and explanation how this works)?

What kind of transmitters do you know?

What are differences between neuropeptides and small molecular transmitters (neuropeptides are in larger vesicles)? Where are those synthesized? Differences in release and function? What is the role of Ca2+ for both (involved in release of both, but different mechanisms)?

What transmitter is used at the end plate? Explain how ACh is removed from the synaptic cleft (see Kandel).

Show cerebellum, name folia.

Difference in anatomy to the cerebral cortex?

What is the typical cell of the cerebellum?

What is the typical cell of the cerebral cortex?

Explain arrangement of parallel fibers and Purkinje cells.

What are input and output of the cerebellum?

What is the function of the cerebellum?

What are other structures for motor control?

What and where are the basal ganglia?

What is a typical disease related to the basal ganglia?

What are symptoms of and reasons for Parkinson?

Where besides the basal ganglia do you find dopaminergic neurons?

What may be the reason that dopaminergic neurons degenerate only in the basal ganglia (cells have a dopamine transporter which also transports harmful substances to the cells)?

What is a treatment for Parkinson?

Sonstiges:

Entspannte Atmosphäre, war mehr wie Gespräch. Ich habe viel erzählt, er hat zugehört und zwischendurch was gefragt. Die Fragen kamen meist, weil ich was erwähnt habe und er ist drauf eingegangen. Die Beisitzerin hat nichts gesagt. Kann ich als Prüfung nur empfehlen, solange man bereit ist viel zu lernen, auch mal Sachen, die in den Vorlesungen definitiv nicht dran kamen, aber im Kandel zu finden sind. Die Benotung ist sehr fair ;-).